Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective release antiviral therapy (LASER ART) and CRISPR-Cas9 demonstrate viral clearance in latent infectious reservoirs in HIV-1 infected humanized mice.
Our Advanced Human Immune System Mouse Models can be used for analyzing all phases of the HIV life cycle. Protective compounds and vaccinations administered before infection, antiviral therapies to prevent replication, and compounds influencing relapse or resistance development have been successfully assessed.
In the HIV hu-mouse models, even brain microglia are humanized. That’s a huge advantage when evaluating compounds to deplete the virus reservoir in the brain that causes HIV-related dementia.