Humanized Liver Mouse Model
The hu-liver (humanized liver) Mouse Model allows researchers to predict the efficacy, drug toxicity, and drug-drug interactions of drug development related to human diseases such as oncology, inflammatory diseases, and infectious diseases.
Drug candidates are profiled for preclinical toxicity, drug metabolism and drug-drug interactions. Predictive studies/data/models remain challenging.
Our team is finalizing a very predictive humanized liver mouse model composed of 100% human hepatocytes, called the hu-liver.
- Human PK/PD
- Hepato Toxicity, Safety profiling
- Human Metabolism and active metabolite characterisation
- Hepatic Viral Infections: HBV, HCV, and others
- NASH (e.g fibrosis)
- Gene-based therapies