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Humanized Liver Mouse Model

Humanized Liver Mouse Model Applications

The hu-liver (humanized liver) Mouse Model allows researchers to predict the efficacy, drug toxicity, and drug-drug interactions of drug development related to human diseases such as oncology, inflammatory diseases, and infectious diseases.

Drug candidates are profiled for preclinical toxicity, drug metabolism and drug-drug interactions. Predictive studies/data/models remain challenging.

Our team has developed a very predictive humanized liver mouse model, called the hu-liver.

Applications:

  • Human PK/PD
  • Hepato Toxicity, Safety profiling
  • Human Metabolism and active metabolite characterisation
  • Hepatic Viral Infections: HBV, HCV, and others
  • NASH (e.g fibrosis)
  • Gene-based therapies
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