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Inflammatory Disorders

Graft-vs-Host Disease (GvHD) Models

GvHD Induction using Immuno-Deficient Mouse Models engrafted with human PBMCs

PBMC from healthy donors are injected in NCG mice – Monitoring of the survival curve and Global clinical score

Example using Cyclosporine A treatment in n=12 mice per group (8-week old), 3 PBMCs donors randomised in the study

Cyclosporine A treatment

  • Cyclosporin-A treatment significantly reduced the mortality and the global clinical score as compared to the vehicle group (PBS)
  • Circulating CD8+ T lymphocytes are decreased by Cyclosporin-A treatment

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