Infectious Disease Mouse Models (HIV, HBV)
HIV humanized mouse models
Infectious Disease Mouse Models for studying HIV, HBV, and other infectious diseases are available from TransCure. HIV is a human specific virus targeting human CD4+ circulating lymphocytes. During the past 10 years, the development of the reconstitution of a fully functional human immune system in immune deficient mouse models has provided the opportunity to develop HIV models. Compared to SIV monkey models, HIV mice are cheaper, safer, and more ethically acceptable. Current tri-therapies are showing similar efficacy on HIV mice as on HIV patients. Combotherapy designs can also be executed with HIV humanized mice.