Cytokine Release Syndrome (CRS) represents a significant challenge in the realm of immunotherapy, characterized by an overwhelming release of pro-inflammatory cytokines leading to severe… Read More »Advancing CRS Preclinical Research with CD34+ Humanized Mice Models for Innovative Therapeutic Development
To describe how a laboratory mouse lives, we will first define what a mouse cage is, then examine the macro and micro-environment of these… Read More »How do laboratory mice live?
The utilization of animals for scientific research is governed by specific legislation that has evolved to acknowledge the sensitivity of animals. It is now… Read More »How to Effectively Assess the Well-being of Laboratory Mice
Liver cancer, specifically hepatocellular carcinoma (HCC), stands as a major global health concern, ranking as the sixth most prevalent cancer and the fourth leading… Read More »Deciphering the Global Challenge of Liver Cancer: Pathophysiology, Advances in Treatment and in vivo Preclinical Mouse Models
The development of curative therapies is a crucial issue for the future management of Non-Alcoholic Liver Disease (NAFLD), and the success of this endeavor… Read More »Modeling NAFLD in Humanized Mice: Upgrading Preclinical Research to Make a Difference in The Search for Innovative Therapies
NAFLD – A global challenge Non-alcoholic liver disease (NAFLD) is the most prevalent chronic liver disease worldwide, affecting more than a third of the… Read More »Advancing NASH Preclinical Research with Humanized Mouse Models for Innovative Therapeutics
Mice are the most commonly used species in animal experimentation. To carry out research protocols, experimenters need to catch and handle them efficiently for… Read More »How to Handle a Laboratory Mouse
The development of CAR-T therapies faces challenges such as limited efficacy, toxicities, antigen escape, and reduced persistence of CAR-T cells. In the previous article,… Read More »Advancing CAR-T Therapy: CAR-T Challenges and Horizon (Part 2)
Discover the innovation of CAR-T therapies, designed to specifically target cancer cells, showing remarkable efficacy against leukemias and lymphomas. This first blog of a… Read More »Advancing CAR-T Therapy: Breakthroughs and Diverse Approaches (Part 1)
Tumor xenograft models are valuable tools for evaluating drug efficacy and safety. Among these models, Patient-Derived Xenografts (PDX) and Cell Line-Derived Xenografts (CDX) are… Read More »How to use Cell line Derived Xenograft (CDX) and Patient Derived Xenograft (PDX) humanized mouse models
